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However, if acyclovir is taken during the first trimester of pregnancy, it may lead to certain complications in the pregnancy. Experience with topical acyclovir use in pregnant women over several decades, based on published literature including observational studies, has not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. The dosage of acyclovir during pregnancy mainly depends on the severity of your condition.. ️ It's most effective if you start to use it as soon as you get the first signs of cold sore developing. Please talk to a pharmacist or your OB to discuss what you can take, put on your body or even consume while pregnant. Cold sores CAN be the herpes virus. Speak to your doctor or pharmacist Is it safe to be consumed during pregnancy? 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